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Test Code LEUKLYMPHEN Leukemia/Lymphoma Phenotyping by Flow Cytometry, Non-blood

Additional Codes

St. Luke's Compendium Code (Iatric): L905.0359

Methodology

Flow Cytometry

Includes flow cytometric analysis with and assortment of lymphocyte and or myeloid-lineage associated antigens.  The appropriate selection of these is chosen by a Mayo Hematopathologist based on clinical information, specimen type, specimen volume, cellular characteristics, and/or morphologic review, keeping in mind the clinical impression of the referrign physician.  This test includes review of morphology for quality correlation with immunophenotypic results.

 

Note: This procedure is applicable for cases of acute lymphoblastic leukemia, acute myelongenous leukemia, chronic lymphoproliferative disorders, and malignant lymphomas.

Specimen Requirements

Bone Marrow

Collect 1-5 mL bone marrow in an ACD Solution B (yellow top) tube and send to the laboratory refrigerated.  Specimen must arrive to the testing facility within 96 hours of collection. 

 

Submission of bilateral specimens is not required.

Include 5-10 unstained bone marrow aspirate smears, if possible.

Label specimen as bone marrow.

 

Test Classification

This test was developed using an analyte specific reagent.  Its performance characteristics were determined by Mayo Clinic in a manner consisten with CLIA requirements.  This test has not been cleared or approved by the U.S. Food and Drug Administration

Reference Range

An interpretive report will be provided.

 

This test will be processed as a laboratory consultation.  An interpretation of the immunophenotypic findings and correlation with the morphologic features will be provded by a hematopathologist for every case.

Testing Algorithm

When a test is ordered a screening panel and a professional interpretation will always be charged.  The screening panel will be charged basd on number of markers tested.  The interpretation will be based on markers tested in increments of 2 to 8, 9 to 15, or 16 and greater.  In addition, reflex testing amy occur to fully characterize a disease state or clarify any abnormalities from the screening test.  Reflex tests will be performed at an additional charge for each marker tested.

 

Note:  FISH or molecular testing may be recommended by the Mayo pathologist in some cases.  They will contact the referring physician or pathologist to confirm the addition of these tests.

CPT Code Information

88184-Flow Cytometry; first cell surface, cytoplasmic or nuclear marker

88185-Flow Cytometry; additional cell surface, cytoplasmic or nuclear marker (each)

88187-Flow Cytometry Interpretation, 2 to 8 markers (if appropriate)

88188-Flow Cytometry Interpretation, 9 to 15 markers (if appropriate)

88189-Flow Cytometry Interpretation, 16 or more markers (if appropriate)