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Test Code GB2GP Beta-2 Glycoprotein 1 Antibodies, IgG, Serum

Additional Codes

St. Luke's Compendium Code (Iatric): L902.3555

Reporting Name

Beta 2 GP1 Ab IgG, S

Useful For

Evaluating patients with suspected antiphospholipid syndrome by identification of beta-2 glycoprotein 1 IgG antibodies

 

First-line test when antiphospholipid syndrome is strongly suspected, in conjunction with cardiolipin antibodies (IgG and IgM) and lupus anticoagulant testing

 

Estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Additional Testing Requirements


Diagnostic criteria for antiphospholipid syndrome include the presence of at least one of the following: lupus anticoagulant, anticardiolipin, and anti-beta-2 glycoprotein 1 IgG or IgM antibodies. Consider ordering CLPMG / Phospholipid (Cardiolipin) Antibodies, IgG and IgM, Serum; MB2GP / Beta-2 Glycoprotein 1 Antibodies, IgM, Serum; and ALUPP / Lupus Anticoagulant Profile, Plasma concurrently with this test.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reference Values

<15.0 SGU (negative)

15.0-39.9 SGU (weakly positive)

40.0-79.9 SGU (positive)

≥80.0 SGU (strongly positive)

Results are reported in standard IgG anti-beta 2 glycoprotein 1 units (SGU).

 

Reference values apply to all ages.

Day(s) Performed

Monday through Saturday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86146

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GB2GP Beta 2 GP1 Ab IgG, S 44448-9

 

Result ID Test Result Name Result LOINC Value
GB2GP Beta 2 GP1 Ab IgG, S 44448-9

Report Available

2 to 6 days

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)